3 minute read

Cenforce unwanted effects are temporary or say minor. 12. Stanopoulos I, Hatzichristou D, Tryfon S, Tzortzis V, Apostolidis A, Argyropoulou P “Effects of sildenafil on cardiopulmonary responses during stress.” J Urol 169 (2003): 1417-21. 34. PadmaNathan H, Steers WD, Wicker PA “Efficacy and safety of oral sildenafil in the treating male impotence: A double-blind, placebo-controlled study of 329 patients.” Int J Clin Pract 52 (1998): 375-9. It’s possible that some unwanted effects of sildenafil may possibly not have been reported.

This is a confusing area, but essentially, if men adhere to buying their erectile dysfunction treatments from UK regulated websites, they can be positive that whether they buy Cenforce or sildenafil, they are going to get medically identical UK licensed medicine. Other side-effects are classified by the table towards the bottom with the page and are repeated within the ‘patient information leaflets’ supplied with the medication - see link below. As Cenforce and sildenafil are medically exactly the same, they’ve got the identical side-effects and interact with other medicines in the same manner.

More in depth information taken from ‘Summary of Product Characteristics’ of Cenforce (the drug license document, data supplied by manufacturers for product licensing) is copied below under the following headings (correct by October 2016): Prior to prescribing sildenafil, physicians should contemplate whether their clients with certain underlying conditions could be adversely suffering from such vasodilatory effects, especially in in conjunction with sexual activity. Interactions along with other treating of erection dysfunction.



To be able to minimise the potential for developing postural hypotension, patients must be hemodynamically stable on alpha-blocker therapy just before initiating sildenafil treatment. Although no increased incidence of adverse events was affecting these patients, when sildenafil is administered concomitantly with CYP3A4 inhibitors, a starting dose of 25mg is highly recommended. Co-administration in the HIV protease inhibitor saquinavir, a CYP3A4 inhibitor, at steady state (1200mg three times per day) with sildenafil (100mg single dose) resulted in a 140% boost in sildenafil Cmax and a 210% rise in sildenafil AUC.

Every time a single 100mg dose of sildenafil was administered with erythromycin, a moderate CYP3A4 inhibitor, at steady state (500mg two tmes a day 5 days), there was clearly a 182% increase in sildenafil systemic exposure (AUC). Although specific interaction studies were not conducted for those medicinal products, population pharmacokinetic analysis showed no effect of concomitant treatment on sildenafil pharmacokinetics when grouped as CYP2C9 inhibitors (including tolbutamide, warfarin, phenytoin), CYP2D6 inhibitors (like selective serotonin reuptake inhibitors, tricyclic antidepressants), thiazide and related diuretics, loop and potassium sparing diuretics, angiotensin converting enzyme inhibitors, calcium channel blockers, beta-adrenoreceptor antagonists or inducers of CYP450 metabolism (such as rifampicin, barbiturates). Concomitant administration of sildenafil to patients taking alpha-blocker therapy can result in symptomatic hypotension using some susceptible individuals.

When sildenafil and doxazosin were administered simultaneously to patients stabilized on doxazosin therapy, there were infrequent reports of patients who experienced symptomatic postural hypotension. Pooling with the following classes of antihypertensive medication; diuretics, beta-blockers, ACE inhibitors, angiotensin II antagonists, antihypertensive medicinal products (vasodilator and centrally-acting), adrenergic neurone blockers, calcium channel blockers and alpha-adrenoceptor blockers, showed no alteration in the side effect profile in patients taking sildenafil when compared with placebo treatment.

To read more about Cenforce 200 go to this useful internet page.